**Core Concept:** Hypospadias is a congenital malformation where the urethral orifice in males is located on the penile shaft or lower, instead of the glans penis. It is a consequence of abnormal development of the genital ducts during pregnancy.

**Why the Correct Answer is Right:** Hypospadias is primarily caused by a deficiency in the production of glucocorticoids during pregnancy, which is a key factor in the normal development of the genital ducts. The correct answer, **Dexamethasone (a synthetic glucocorticoid)**, is a potent anti-inflammatory drug used to prevent respiratory distress syndrome in premature infants. Its administration during pregnancy can lead to impaired development of the genital ducts, causing hypospadias.

**Why Each Wrong Option is Incorrect:**

A. **Methotrexate:** Although an immunosuppressive agent, methotrexate is not a synthetic glucocorticoid and does not cause hypospadias due to its lack of direct effect on genital duct development.

B. **Methotrexate:** Similar to methotrexate, cyclosporine is an immunosuppressive agent but does not affect genital duct development.

C. **Ibuprofen:** An anti-inflammatory drug, ibuprofen is not a synthetic glucocorticoid and does not cause hypospadias due to its lack of direct effect on genital duct development.

**Clinical Pearl:** Hypospadias is a preventable condition in some cases by avoiding medications, such as dexamethasone, during pregnancy. Healthcare professionals should counsel pregnant women about potential risks and provide alternatives for necessary medications. Early detection and management of hypospadias can significantly improve outcomes for affected infants.