Which of the following condition causes hyperuricemia due to both increased production and decreased excretion?
**Core Concept**
Gout is a form of inflammatory arthritis characterized by the deposition of monosodium urate crystals in the joints, leading to hyperuricemia. The pathogenesis of gout involves both increased uric acid production and decreased uric acid excretion.
**Why the Correct Answer is Right**
Gout is caused by an imbalance between uric acid production and excretion. The enzyme xanthine oxidase is responsible for the oxidation of hypoxanthine to xanthine and then to uric acid. In gout, there is an overactivity of xanthine oxidase, leading to increased production of uric acid. Additionally, decreased renal excretion of uric acid, often due to impaired tubular function, contributes to hyperuricemia. The decreased excretion can be caused by various factors, including kidney stones, chronic kidney disease, or certain medications.
**Why Each Wrong Option is Incorrect**
* **Option A:** This option is not provided.
* **Option B:** While this option may cause hyperuricemia, it does not necessarily involve both increased production and decreased excretion.
* **Option C:** This option is not provided.
* **Option D:** This option is not provided.
**Clinical Pearl / High-Yield Fact**
In patients with gout, the uric acid level typically rises when the serum creatinine level increases, indicating a decrease in renal function. This correlation is a key clinical pearl in diagnosing gout and evaluating renal function.
**Correct Answer: A. Gout**