**Core Concept**
Multiple endocrine neoplasia (MEN) syndromes are hereditary disorders characterized by the occurrence of tumors in multiple endocrine glands, leading to excessive hormone production and various clinical manifestations.
**Why the Correct Answer is Right**
The patient's symptoms suggest a diagnosis of Multiple Endocrine Neoplasia Type 1 (MEN1). MEN1 is caused by mutations in the MEN1 gene, which encodes a tumor suppressor protein involved in the regulation of cell growth and differentiation. The combination of hyperparathyroidism, pancreatic islet cell tumors, adrenal cortical hyperplasia, pituitary adenomas, and cutaneous angiofibromas is consistent with MEN1. The development of these tumors is thought to result from the loss of function of the MEN1 protein, leading to uncontrolled cell growth and tumor formation.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because MEN2A is characterized by medullary thyroid carcinoma, pheochromocytoma, and primary hyperparathyroidism, but not the combination of symptoms described in the patient.
**Option B:** This option is incorrect because MEN2B is characterized by medullary thyroid carcinoma, pheochromocytoma, and mucosal neuromas, but not the combination of symptoms described in the patient.
**Option C:** This option is incorrect because Carney complex is a rare genetic disorder characterized by multiple endocrine tumors, skin and cardiac myxomas, but not the combination of symptoms described in the patient.
**Option D:** This option is incorrect because Wermer syndrome is an alternative name for MEN1, but it is not a distinct clinical entity.
**Clinical Pearl / High-Yield Fact**
MEN1 is inherited in an autosomal dominant pattern, meaning that a single copy of the mutated gene is sufficient to cause the disorder. This means that individuals with a family history of MEN1 should be screened for mutations in the MEN1 gene.
**Correct Answer:** C. Carney complex
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