Diuretic used in essential hypeension is –
**Core Concept**
The question is testing the student's knowledge of antihypertensive medications, specifically diuretics used in the management of essential hypertension. Diuretics are a class of medications that increase urine production, thereby reducing blood volume and lowering blood pressure.
**Why the Correct Answer is Right**
The correct answer is a thiazide diuretic, which works by inhibiting the sodium-chloride cotransporter in the distal convoluted tubule of the nephron. This leads to increased sodium and chloride excretion in the urine, resulting in decreased blood volume and subsequently, a decrease in blood pressure. Thiazide diuretics are commonly used in the treatment of essential hypertension due to their effectiveness in reducing blood pressure and their tolerability.
**Why Each Wrong Option is Incorrect**
* **Option A:** This option is incorrect because loop diuretics, such as furosemide, are more potent than thiazide diuretics and are typically used in cases of edema or heart failure, rather than essential hypertension.
* **Option B:** This option is incorrect because potassium-sparing diuretics, such as spironolactone, are used to manage conditions like primary aldosteronism or hypertension resistant to other treatments, but are not typically used as first-line therapy for essential hypertension.
* **Option C:** This option is incorrect because calcium channel blockers, such as amlodipine, are a different class of antihypertensive medications that work by relaxing blood vessels, rather than increasing urine production.
**Clinical Pearl / High-Yield Fact**
Thiazide diuretics are often used in combination with other antihypertensive medications, such as beta blockers or ACE inhibitors, to achieve optimal blood pressure control. This combination is known as a "stepped care" approach, where the goal is to use the least number of medications necessary to achieve target blood pressure levels.
**Correct Answer:** B. Hydrochlorothiazide