Deficiency of Vitamin-E causes all, except:
**Core Concept**
Vitamin E is an essential fat-soluble antioxidant that plays a crucial role in protecting cell membranes from oxidative damage, particularly in the nervous system and red blood cells. Its deficiency can lead to various clinical manifestations due to increased lipid peroxidation and cell damage.
**Why the Correct Answer is Right**
Vitamin E deficiency is known to cause neurological problems, including peripheral neuropathy, ataxia, and cognitive impairment. This is because Vitamin E is crucial for the maintenance of myelin sheaths in the nervous system, and its deficiency can lead to demyelination and axonal damage. Additionally, Vitamin E deficiency can cause hemolytic anemia due to its role in protecting red blood cells from oxidative stress.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because Vitamin E deficiency does not directly cause cataracts. Cataracts are more commonly associated with antioxidant deficiencies like Vitamin C and beta-carotene, which are involved in protecting lens proteins from oxidative damage.
**Option B:** This option is incorrect because Vitamin E deficiency is not directly associated with increased risk of cardiovascular disease. While Vitamin E has antioxidant properties, its deficiency is not a primary risk factor for cardiovascular disease.
**Option C:** This option is incorrect because Vitamin E deficiency is not directly associated with increased risk of osteoporosis. Vitamin D and calcium are more commonly associated with bone health and osteoporosis.
**Clinical Pearl / High-Yield Fact**
Vitamin E deficiency can be caused by a variety of factors, including malabsorption, liver disease, and genetic disorders like abetalipoproteinemia.
**Correct Answer: D.**