**Core Concept**
Colistin is a polymyxin antibiotic that belongs to the class of cationic polypeptide antibiotics. It is used to treat infections caused by multidrug-resistant Gram-negative bacteria. The mechanism of action of colistin involves binding to the bacterial cell membrane, disrupting its structure, and ultimately leading to bacterial cell death.
**Why the Correct Answer is Right**
Colistin is obtained from the bacterium Paenibacillus polymyxa, a gram-positive bacterium found in soil. The name "polymyxin" refers to the fact that this bacterium produces multiple antibiotics, including colistin. The production of colistin is a result of the bacterium's natural defense mechanism to sequester cations and protect itself from environmental stress.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because it is not related to the production of colistin.
**Option B:** This option is incorrect because it is a different class of antibiotics altogether.
**Option C:** This option is incorrect because it is not a known source of colistin.
**Clinical Pearl / High-Yield Fact**
It is essential to note that colistin is not absorbed well orally and is usually administered intravenously or intramuscularly. Additionally, colistin can cause nephrotoxicity and neurotoxicity as side effects, and its use should be carefully monitored in patients with pre-existing kidney or neurological conditions.
**Correct Answer: C. Paenibacillus polymyxa**
Free Medical MCQs Β· NEET PG Β· USMLE Β· AIIMS
Access thousands of free MCQs, ebooks and daily exams.
By signing in you agree to our Privacy Policy.