Cochlear involvement more than vestibular involvement drug ?
**Core Concept**
The question is testing the student's knowledge of the effects of certain ototoxic drugs on the cochlea and vestibular system. Ototoxicity is a form of toxicity caused by chemicals that can damage the inner ear, particularly the cochlea and vestibular system.
**Why the Correct Answer is Right**
The correct answer is related to the drug that has a higher affinity for the stria vascularis in the cochlea, leading to damage and hearing loss. The stria vascularis is responsible for maintaining the endolymphatic potential in the cochlea and is particularly sensitive to ototoxic drugs. The correct answer is aminoglycoside antibiotics, such as gentamicin, which are known to cause cochlear damage more frequently than vestibular damage.
**Why Each Wrong Option is Incorrect**
* **Option A:** This option is incorrect because it does not specifically mention a drug that is known to cause cochlear damage more frequently than vestibular damage.
* **Option B:** This option is incorrect because it does not accurately describe the effects of the mentioned drug on the cochlea and vestibular system.
* **Option C:** This option is incorrect because it does not specifically mention a drug that is known to cause cochlear damage more frequently than vestibular damage.
**Clinical Pearl / High-Yield Fact**
Aminoglycoside antibiotics, such as gentamicin, can cause irreversible cochlear damage, particularly with high doses or prolonged treatment. This is why monitoring of auditory function is essential in patients receiving these medications.
**Correct Answer: C. Aminoglycosides.**