A patient with Hodgkin’s lymphoma presents with isolated cervical lymphadenopathy. Biopsy from the lesion shows characteristic lacunar cells. The treatment of choice for this patient is:
## Core Concept
The question tests knowledge of Hodgkin's lymphoma, specifically the nodular sclerosis subtype, which is characterized by the presence of **lacunar cells** and often presents with cervical lymphadenopathy. Treatment choices for Hodgkin's lymphoma depend on the stage and histological subtype.
## Why the Correct Answer is Right
The presence of **lacunar cells** in the biopsy is indicative of **nodular sclerosis**, a common subtype of Hodgkin's lymphoma, especially in young adults. Given that the disease is in an **early stage** (isolated cervical lymphadenopathy), the treatment of choice leans towards **chemotherapy and/or radiotherapy**. Among the options, **ABVD (Adriamycin, Bleomycin, Vinblastine, Dacarbazine) chemotherapy regimen** is a standard first-line treatment for Hodgkin's lymphoma, particularly for early-stage disease, making it the most appropriate choice.
## Why Each Wrong Option is Incorrect
- **Option A:** This option is blank and cannot be evaluated.
- **Option B:** This option is blank and cannot be evaluated.
- **Option D:** This option is blank and cannot be evaluated.
## Clinical Pearl / High-Yield Fact
A key point to remember is that **ABVD** has become a standard regimen for Hodgkin's lymphoma due to its efficacy and lower long-term toxicity profile compared to older regimens like **MOPP (Mechlorethamine, Oncovin, Procarbazine, Prednisone)**. The presence of lacunar cells and the early-stage presentation make **ABVD** a preferred choice.
## Correct Answer Line
**Correct Answer: C. ABVD.**