**Core Concept**
The question is testing the clinical correlation between breath sounds and airway obstruction. In patients with significant airway obstruction, the increased resistance to airflow prolongs the time for air to escape from the lungs during forced expiration, resulting in prolonged breath sounds.

**Why the Correct Answer is Right**
The correct answer is based on the principle that significant airway obstruction prolongs the time for air to escape from the lungs during forced expiration, leading to prolonged breath sounds. This is due to the increased resistance to airflow in the obstructed airway, which slows down the rate of air escape. The prolonged breath sounds are a result of the prolonged time for air to escape from the lungs.

**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because it does not provide a specific time frame for breath sounds to be considered significant. Prolonged breath sounds can occur at any time frame, not just after 2 seconds.
**Option B:** This option is incorrect because it is too short a time frame. Breath sounds audible for less than 2 seconds may not necessarily indicate significant airway obstruction.
**Option C:** This option is incorrect because it is too long a time frame. Breath sounds audible for more than 5 seconds may indicate other conditions, such as chronic obstructive pulmonary disease (COPD), but it is not specific to significant airway obstruction.

**Clinical Pearl / High-Yield Fact**
In patients with significant airway obstruction, the prolonged breath sounds are often associated with a "tracheal tug" or "tracheal pull" sign, which is a visible displacement of the trachea during forced expiration.

**Correct Answer: C. 5 seconds**