All true about sodium Thiopentone except:-
**Core Concept**
Sodium Thiopentone is a barbiturate derivative used as an induction agent in anesthesia, known for its rapid onset of action and short duration of effect. It acts by enhancing the inhibitory neurotransmission mediated by GABA (gamma-aminobutyric acid) in the central nervous system.
**Why the Correct Answer is Right**
Sodium Thiopentone exerts its effects by binding to the GABA_A receptor, a pentameric complex composed of Cl- channels, and increasing the frequency of chloride channel opening. This leads to an influx of chloride ions into the neuron, resulting in hyperpolarization and a decrease in neuronal excitability. Sodium Thiopentone also has a high lipid solubility, which allows it to rapidly cross the blood-brain barrier and exert its effects within seconds of administration.
**Why Each Wrong Option is Incorrect**
**Option A:** Incorrect because Sodium Thiopentone is indeed a barbiturate derivative and is used as an induction agent in anesthesia.
**Option B:** Incorrect because Sodium Thiopentone does have a high lipid solubility, which facilitates its rapid onset of action.
**Option C:** Incorrect because Sodium Thiopentone does act by enhancing GABA-mediated inhibitory neurotransmission.
**Clinical Pearl / High-Yield Fact**
Sodium Thiopentone can cause a decrease in cerebral metabolic rate and cerebral blood flow, making it a useful agent in neurosurgical procedures where maintaining a stable intracranial pressure is crucial. However, it can also cause a rebound increase in intracranial pressure after its effects wear off, making close monitoring of patients essential.
**Correct Answer:** Not Provided