All of the following are associated with hypergonadotrophic hypogonadism in males, EXCEPT:
Correct Answer: Kallman's syndrome
Description: Kallman's syndrome is associated with hypogonadotropic hypogonadism resulting in decreased or absent GnRHsecretion. This syndrome is characterized clinically by anosmia, hypogonadism and other midline defects (cleft lip/palate, colour blindness, seizures, anosmia etc). This syndrome is due to impaired migration of GnRH releasing neurons to hypothalamus during the embryonic period. Ref: Cancer and Sexual Health By John P. Mulhall page 197; Organic psychiatry: the psychological consequences of cerebral disorder By William Alwyn Lishman page 526; Manual of Endocrinology and Metabolism By Norman Lavin page 292; The immunoassay handbook By David Wild page 567
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