True about anaphylactoid reaction caused by NSAIDs-
**Core Concept**
Anaphylactoid reactions are non-immunological, immediate hypersensitivity reactions that mimic anaphylaxis but are not mediated by specific antibodies. These reactions can be caused by various substances, including NSAIDs, which lead to the release of histamine and other mediators from mast cells.
**Why the Correct Answer is Right**
NSAIDs cause anaphylactoid reactions by inhibiting the enzyme cyclooxygenase (COX), which is responsible for the production of prostaglandins and thromboxanes. This inhibition leads to an imbalance in the arachidonic acid pathway, resulting in the release of histamine from mast cells. The released histamine then causes blood vessels to dilate, smooth muscle to contract, and mucous membranes to swell, leading to the characteristic symptoms of anaphylaxis.
**Why Each Wrong Option is Incorrect**
**Option A:** Incorrect because anaphylactoid reactions are not mediated by specific antibodies, unlike anaphylactic reactions.
**Option B:** Incorrect because while NSAIDs can cause anaphylaxis, it is not the most accurate description of an anaphylactoid reaction.
**Option C:** Incorrect because this option is too broad and does not specifically describe the mechanism of an anaphylactoid reaction caused by NSAIDs.
**Clinical Pearl / High-Yield Fact**
When prescribing NSAIDs, it is essential to consider the patient's history of allergies and asthma, as these conditions increase the risk of an anaphylactoid reaction.
**Correct Answer:**
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