All are true about hepatic adenoma Except
**Core Concept**
Hepatic adenomas are benign, epithelial tumors of the liver, often associated with hormonal influences, particularly estrogen. They are characterized by their growth in a well-defined, capsule-like structure and are usually solitary.
**Why the Correct Answer is Right**
Hepatic adenomas are indeed typically solitary, well-circumscribed lesions. These tumors are also known to be associated with hormonal influences, particularly estrogen, which can lead to their growth and development. Furthermore, they are often linked to the use of oral contraceptives, which contain estrogen. The pathogenesis of hepatic adenomas involves the activation of various signaling pathways, including the PI3K/AKT and MAPK/ERK pathways, which contribute to their growth and proliferation.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect as hepatic adenomas are not typically multiple or diffuse. They are usually solitary lesions.
**Option B:** This option is incorrect as hepatic adenomas are not typically malignant. They are benign tumors.
**Option C:** This option is incorrect as hepatic adenomas are not typically associated with a poor prognosis. They are usually resectable and have a good prognosis if removed surgically.
**Clinical Pearl / High-Yield Fact**
It's essential to note that hepatic adenomas are often linked to the use of oral contraceptives, which contain estrogen. This is a critical piece of information for clinicians, as it may influence the management and treatment of these patients.
**Correct Answer: B. Hepatic adenomas are malignant.**