All are true about cefuroxime Except :
**Core Concept**
Cefuroxime is a second-generation cephalosporin antibiotic with a broad spectrum of activity against both Gram-positive and Gram-negative bacteria. It is effective against a variety of infections, including respiratory tract, skin, and soft tissue infections.
**Why the Correct Answer is Right**
Cefuroxime has a similar mechanism of action to other cephalosporins, inhibiting cell wall synthesis by binding to penicillin-binding proteins (PBPs) on the bacterial cell wall. This leads to the disruption of the bacterial cell wall and ultimately, bacterial cell death. Cefuroxime is also known for its ability to cross the blood-brain barrier, making it effective against meningitis and other central nervous system infections.
**Why Each Wrong Option is Incorrect**
**Option A:** (insert correct answer choice letter)
Cefuroxime is not a first-generation cephalosporin, which primarily target Gram-positive bacteria. It is a second-generation cephalosporin, with a broader spectrum of activity.
**Option B:** (insert correct answer choice letter)
Cefuroxime is not a third-generation cephalosporin, which have a narrower spectrum of activity but are more effective against Gram-negative bacteria.
**Option C:** (insert correct answer choice letter)
Cefuroxime does not have a unique mechanism of action that sets it apart from other cephalosporins.
**Clinical Pearl / High-Yield Fact**
Cefuroxime is often used in combination with other antibiotics to treat infections caused by resistant bacteria. It is also effective against beta-lactamase-producing bacteria, which are resistant to many other antibiotics.
**Correct Answer:** A.