Acetazolamide is associated with:
Correct Answer: Metabolic acidosis
Description: The carbonic anhydrase-inhibiting drugs are only moderately effective as diuretic agents, but because they inhibit acid secretion by decreasing the supply of carbonic acid, they have far-reaching effects. Not only is Na+ excretion increased because H+ secretion is decreased, but also HCO3- reabsorption is depressed; and because H+ and K+ compete with each other and with Na+, the decrease in H+ secretion facilitates the secretion and excretion of K+. Ref: Ganong's Review of Medical Physiology 23rd edition, Chapter 38.
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