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9298 Pharmacology

A three year old child is brought to the emergency department having just ingested a large overdose of an antihistaminic drug. This drug is a weak base capable of entering most tissues including the brain. On physical examination the heart rate is 100/ minute, blood pressure is 110/60 mm Hg and the respiratory rate is 20/ minute. In this case of poisoning:

AUrinary excretion would be accelerated by administration of NH4Cl, an acidifying  agent
BUrinary excretion would be accelerated by administration of NaHCO3, an  alkalinizing agent
CMore of the drug would be ionized at blood pH than at stomach pH
DAbsorption of the drug would be faster from the stomach than from the small intestine
Pharmacology
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9303 Pharmacology

Acetazolamide is:

ACompetitive and reversible carbonic anhydrase inhibitor
BNon-competitive and reversible carbonic anhydrase inhibitor
CCompetitive and irreversible carbonic anhydrase inhibitor
DNon-competitive and irreversible carbonic anhydrase inhibitor
Pharmacology
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