**Core Concept**
Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit cyclooxygenase (COX) enzymes, which are crucial for the production of prostaglandins. COX-2 inhibitors, like other NSAIDs, reduce inflammation by selectively inhibiting COX-2, a subtype of the enzyme that is predominantly involved in the inflammatory process.
**Why the Correct Answer is Right**
Celecoxib (Wof) is an injectable COX-2 inhibitor used for the treatment of inflammation and pain in various conditions, such as osteoarthritis and rheumatoid arthritis. By selectively inhibiting COX-2, celecoxib reduces the production of prostaglandins, which are mediators of inflammation. This mechanism of action allows celecoxib to provide anti-inflammatory and analgesic effects with fewer gastrointestinal side effects compared to non-selective NSAIDs.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because it is a non-selective COX inhibitor, which would have a higher risk of gastrointestinal side effects.
**Option B:** This option is incorrect because it is a selective COX-1 inhibitor, which would not be effective for reducing inflammation.
**Option C:** This option is incorrect because it is an opioid analgesic, which would not be classified as a COX-2 inhibitor.
**Clinical Pearl / High-Yield Fact**
Celecoxib and other COX-2 inhibitors should be used with caution in patients with cardiovascular disease due to the increased risk of myocardial infarction and stroke.
**Correct Answer:** C.
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