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7702 Pathology

A 13-year-old girl has two non-tender lesions on her fingers that have appeared over the past 5 months. On physical examination, there are 0.5-cm slightly raised, pebbly-surfaced, gray-white papules, one on the dorsum of her distal right index finger, and another periungual to her little finger. They gradually disappear over the next 18 months. Which of the following is the most likely factor in the pathogenesis of her lesions?

ABRAF gene mutation
BHuman papillomavirus infection
CIgA antibody deposition
DType IV hypersensitivity reaction
Pathology
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7704 Pathology

An 8-year-old girl with numerous hypopigmented, ulcerated, and crusted patches on her face and forearms develops an indurated, crater-like, skin nodule on the back of her left hand. Biopsy of this skin nodule discloses a squamous cell carcinoma. Molecular biology studies reveal that this patient has germline mutations in the gene encoding a nucleotide excision repair enzyme. What is the appropriate diagnosis?

AAtaxia telangiectasia
BHereditary albinism
CLi-Fraumeni syndrome
DXeroderma pigmentosum
Pathology
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