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7315 Pathology

A 26-year-old man has noted lumps in his neck that have been enlarging for the past 6 months. On physical examination, he has a group of enlarged, nontender right cervical lymph nodes. A biopsy of one of the lymph nodes microscopically shows macrophages, lymphocytes, neutrophils, eosinophils, and a few plasma cells. There are scattered CD15+ large cells with multiple nuclei or a single nucleus with multiple nuclear lobes, each with a large inclusion-like nucleolus. What is the most likely cell of origin with infectious agent for these large cells?

AB lymphocyte, Epstein-Barr virus
BCD4+ cell, human T lymphotropic virus
CEndothelial cell, Kaposi sarcoma herpesvirus
DMacrophage, human immunodeficiency virus
Pathology
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