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7236 Pathology

An 8-year-old boy presents with periorbital edema and throbbing headaches. His parents report that the boy had a “strep throat” 2 weeks ago. Urinalysis shows 3+ hematuria. A renal biopsy shows hypercellular glomeruli, and electron microscopic examination of glomeruli discloses subepithelial “humps.” Which of the following best explains the pathogenesis of glomerulonephritis in this patient?

AAntineutrophil cytoplasmic autoantibodies
BDeposition of circulating immune complexes
CDirectly cytotoxic IgG and IgM antibodies
DIgE-mediated mast cell degranulation
Pathology
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