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4224 Pathology

A 45-year-old man complains of recurrent nausea and abdominal distress. A gastric biopsy shows atrophy of the mucosa in the fundus and body, with marked lymphocytic infiltration. Blood studies show severe macrocytic anemia with a mean corpuscular volume of 110 mm3. In addition, numerous hypersegmented neutrophils are appreciated on a blood smear. Which of the following is the MOST likely pathogenetic mechanism of this patient’s anemia?

AAutoantibodies to intrinsic factor
BChronic blood loss
CDeficient iron absorption
DHelicobacter pylori infection
Pathology
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