15130 Pathology An 18-year-old man moves from sea level to an elevation of 2,400 m to train as a skier. The increased requirement for oxygen delivery to tissues at the higher elevation stimulates the synthesis of a renal hormone (erythropoietin), which targets hematopoietic stem cells in the bone marrow. Erythropoietin promotes the survival of early erythroid progenitor cells primarily through which of the following mechanisms? AAltered cell-matrix adhesionBDownregulation of p53CEnhanced glucose uptakeDInhibition of apoptosis (Correct Answer)
15131 Pathology Lysosomal transpo defect is seen in ACystinosis (Correct Answer)BGoucher's diseaseCMetachromatic leukosytrophyDTay Sach's disease
15132 Pathology Actions of Bradykinin include all of the following, EXCEPT: AVasodilatationBBronchodilatation (Correct Answer)CIncreased vascular permeabilityDPain
15133 Pathology Multiple myeloma most common part involved is- ABone marrow (Correct Answer)BCortex of boneCMetaphysesDEpiphyses
15134 Pathology Which of the following is associated with > 20% risk of chromosomal anomalies? AOmphalocele (Correct Answer)BGastroschisisCCleft lipDSpina bifida
15135 Pathology Von Willebrand&;s factor is synthesized in which one of the following – AVascular endothelium (Correct Answer)BMacrophagesCLiverDEosinophils
15136 Pathology Venous congestion of liver affects ? AMidzoneBPerihepatic zoneCCentrilobular zone (Correct Answer)DAll the above
15137 Pathology A 30-year-old woman sustained a traumatic blow to her right breast. Initially, there was a 3-cm contusion beneath the skin that resolved within 3 weeks, but she then felt a firm, painless lump that persisted below the site of the bruise 1 month later. What is the most likely diagnosis for this lump? AAbscessBFat necrosis (Correct Answer)CFibroadenomaDInflammatory carcinoma
15138 Pathology All of the following statements about hairy cell leukemia are true except: ASplenomegaly is conspicuousBResults from an expansion of neoplastic T-lymphocytes (Correct Answer)CCells are positive for Taarate Resistant Acid phosphataseDThe cells express CD25 consistently