**Core Concept**
Venous congestion of the liver leads to a specific pattern of liver damage due to the unique anatomy of the hepatic vasculature. The liver receives both arterial and venous blood, which are then distributed to the hepatocytes through a complex network of sinusoids.

**Why the Correct Answer is Right**
Venous congestion, also known as sinusoidal congestion, affects the centrilobular zone of the liver. This region is characterized by a high concentration of hepatocytes and is located at the periphery of the liver lobule. The centrilobular zone receives blood from the hepatic veins, which are prone to congestion in the setting of right heart failure or other conditions that impair venous return. As a result, the hepatocytes in this region become hypoxic and undergo necrosis due to the lack of oxygen and nutrients.

**Why Each Wrong Option is Incorrect**
**Option A:** The midzone of the liver lobule is not directly affected by venous congestion. This region receives blood from both the hepatic artery and the hepatic portal vein, making it less susceptible to congestion.

**Option B:** The perihepatic zone is not a recognized term in liver pathology. While the periportal zone is a valid term, it refers to the region surrounding the central vein and is not the primary area affected by venous congestion.

**Clinical Pearl / High-Yield Fact**
It's essential to remember that the centrilobular zone is particularly vulnerable to hypoxia and ischemia due to its unique anatomy and blood supply. This knowledge is crucial in understanding the pathophysiology of various liver disorders, including those caused by venous congestion.

**✓ Correct Answer: C. Centrilobular zone**