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12025 Pathology

Osmotic fragility is:

ANegative in iron deficiency anaemia
BNegative in autoimmune hemolyticanaemia
CBased on the principle of lysis in serial dilutions of hypertonic saline
DBest if performed in citrated blood sample
Pathology
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12027 Pathology

A 38-year-old woman has had malaise and arthralgias for the past 14 months. On physical examination, she has scleral icterus and 1- to 3-cm areas of reddish-purple discoloration on her skin. Several of these areas show focal ulceration. Laboratory findings show total protein, 7.1 g/dL; albumin, 3.3 g/dL; AST, 127 U/L; ALT, 145 U/L; alkaline phosphatase, 80 U/L; total bilirubin, 4 mg/dL; and direct bilirubin, 3.1 mg/dL. Serologic test results are positive for anti-HCV and negative for anti-HBs and IgM anti-HAV. Urinalysis shows 4+ proteinuria and 1+ hematuria. CT scan of the abdomen shows a small amount of ascites, mild hepatomegaly, and no splenomegaly or lymphadenopathy. A biopsy specimen of an ulcerated skin lesion shows leukocytoclastic vasculitis involving the upper dermis. What is the most likely diagnosis?

AAutoimmune hemolytic anemia
BHepatocellular carcinoma
CHereditary hemochromatosis
DMixed cryoglobulinemia
Pathology
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