Organised glomerular deposits in kidney is present in-
## **Core Concept**
The question tests knowledge of kidney pathology, specifically the types of deposits found in glomerular diseases. Organized glomerular deposits refer to structured deposits within the glomeruli, which can be seen in certain kidney diseases. These deposits can be composed of various materials, including immune complexes, amyloid, or other substances.
## **Why the Correct Answer is Right**
The correct answer, **C. Lupus nephritis**, is associated with organized glomerular deposits. In Lupus nephritis, which is a kidney manifestation of systemic lupus erythematosus (SLE), immune complexes can deposit in the glomeruli. These deposits can sometimes be organized, forming structures like "wire loop" lesions or proliferative glomerulonephritis with organized deposits. The presence of organized deposits helps in the diagnosis and classification of Lupus nephritis.
## **Why Each Wrong Option is Incorrect**
- **Option A:** Minimal change disease is characterized by the loss of foot processes of podocytes and absence of significant deposits on electron microscopy, not organized glomerular deposits.
- **Option B:** Diabetic nephropathy primarily involves changes such as mesangial expansion, basement membrane thickening, and Kimmelstiel-Wilson nodules, but not typically organized glomerular deposits.
- **Option D:** IgA nephropathy (Berger's disease) involves the deposition of IgA antibodies in the glomeruli, but these deposits are typically not described as organized.
## **Clinical Pearl / High-Yield Fact**
A key point to remember is that organized glomerular deposits are a hallmark of certain autoimmune and immune-mediated glomerulonephritides. The presence of such deposits can guide the diagnosis and management of kidney diseases. For example, "wire loop" lesions are a classic finding in Lupus nephritis.
## **Correct Answer: C. Lupus nephritis**