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3904 Medicine

CD 19 positive, CD 22 positive, CD103 positive monoclonal B-cells with bright kappa positivity were found to comprise 60% of the peripheral blood lymphoid cells on flow cytometric analysis in a 55 year old man with massive splenomegaly and a total leucocyte count of 3.3 × 109/L. Which one of the following is the most likely diagnosis?

ASplenic lymphoma with villous lymphocytes
BMantle cell lymphoma
CB-cell prolymphocytic leukemia
DHairy cell leukemia
Medicine
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