A 39-year-old woman is evaluated for severe left hip pain after twisting her leg. She has bony deformities of the lower extremities with limited mobility. The patient had a history of precocious pubey, hypehyroidism, which was managed by radioiodine therapy. Physical examination shows large, hyperpigmented-macules with irregular borders located on the left shoulder, left side of neck and left buttock. Which of the following gene is involved in this condition?