Medical MCQ
MCQ Ebook
Biochemistry
Microbiology
Pathology
All MCQs
Term Of Use
Privacy Policy
Contact Us
About Us
Search for:
Home
Ebooks
Questions
Search
Surgery
A middle-aged man presents with a markedly enlarged tonsil and recurrent infections with serum immunoglobulin deficiency. Chromosome analysis demonstrates a translocation between the immunuglobulin heavy chain locus on chromosome 14 and an unidentified gene on chromosome 8. Which of the following is the most likely cause of his phenotype?
The translocation has deleted constant chain exons on chromosome 14 and prevented heavy chain class switching
The translocation has deleted the interval containing diversity d. and joining (J) regions
The translocation has activated a tumor-promoting gene on chromosome 8
The translocation has deleted the heavy chain constant chain Cu so that virgin B cells cannot produce IgM on their membranes
Questions
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100