LungIn Female Breast > LungIn Children Neuroblastoma.Most common cause of osteolytic metastasis.In male Lung Cancer.In Females----- Breast CancerMost common cause of osteoblastic metastasisIn males Prostate CancerIn females Breast CancerSkeletal sites most frequently involved.Spine > proximal femur > pelvis > ribs > sternum > proximal humerus > skullLytic expansile metastasis seen inRenal CancerThyroid carcinoma.Bone metastasis with soft tissue mass.Renal CancerThyroid carcinoma.Osteolytic lesions are associated with hypercalcemia and excretion of hydroxyproline - containing peptides.Osteoblastic lesions are associated with increased levels of serum alkaline phosphatase.Metastasis distal to knee and elbow is rare and usually arises from a primary tumors of theBronchusColon orBladder.">