Physiology

Which of the following statement is true regarding binding of O2 to hemoglobin?

Results in a release of the heme from the interior to the exterior of the Beta subunits leading to an increase in O2 affinity of the alpha subunits

Causes a large shift of the surrounding secondary structures which leads to decreased affinity of the deoxy subunits for CO2

Is Cooperative, meaning that after the first O2 binds, the other subunits are more readily oxygenated

Occurs with equal affinity at all four subunits