ProteinsNOTE: Bicarbonate is the predominant buffer of ECF as a wholeHemoglobin is the predominant buffer of blood as a whole because hemoglobin is present in large amounts the hemoglobin in blood has six times the buffering capacity of the plasma proteinsAlthough hemoglobin is intracellular (inside RBC), it is often considered ECF buffer because RBC is a cellular component of ECF and because of the cellular permeability of RBC membrane.">