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Physiology
Thrombomodulin-thrombin complex prevents clotting because
Thrombomodulin inhibits prothrombin activator
Thrombomodulin-thrombin complex activities anti-thrombin III
The binding of thrombomodulin with thrombin removes thrombin and also activities a plasma protein C which inactivates activated factors V & VIII
Thrombomodulin-thrombin complex activates heparin
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