.16 seconds Arryhthmias Hypotension Hypotension Give intravenous fluids Hypotension results from depression of myocardial contractility and peripheral vasodilatation. In cases refractory to the use of intravenous fluids inotropic agents may be required. Arryhthmias In general antiarryhthmic agents should be avoided and the correction of hypoxia, hypotension, acidosis, hypokalemia should be done to reduce the cardiotoxic effects of tricyclics. Seizures Seizures are usually self limiting but where t/t is necessary benzodiazepenes are the t/t of choice. Cardiac arrest Prolonged resuscitation may be required. Drug elimination Tricyclic specific antibody fragments have been developed and their effectiveness at reversing cardiovascular toxicity in animals has been demonstrated by several studies. However, experimental work has shown that extremely large amounts are required and at present the use of Fab fragments is limited by cost and possibility of renal toxic effects. Hemodialysis and hemoperfusion not effective.">