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Pharmacology
A new diuretic is being studied in human volunteers. Compared with placebo, the new drug increases urine volume, decreases urinary Ca2+, increases body pH, and decreases serum K+. If this new drug has a similar mechanism of action to an established diuretic, it probably
blocks the NaCl cotransporter in the DCT
blocks aldosterone receptors in the CT
inhibits carbonic anhydrase in the PCT
inhibits the Na/K/2Cl cotransporter in the TAL
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