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Pharmacology
A 15-year-old boy is subjected to recurrent attacks of asthma. A careful clinical history reveals that the asthma attacks occur most frequently after aspirin administration. Which of the following is the pathogenetic mechanism in this form of asthma?
Direct release of bronchoconstrictor mediators
Enhanced sensitivity to vagal stimulation
Inhibition of cyclooxygenase pathway
Type I hypersensitivity reaction
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