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Pharmacology
Despite their sho half lives(2hrs) proton pump inhibitors cause a prolonged suppresion of acid secretiin(upto 48hr) because:
They are prodrugs and undergo activation gradually
They exit from the palsma and enter acid secretory canaliculi and stay there blocking the secretion of acid for a long time
They irreversibly inhibit the proton pump molecule and hence,acid secretion requires synthesis of new proton pumps
They are available as enteric coated capsules,from which drug is gradually released
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