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Pharmacology
In the treatment of undiagnosed megaloblastic anemia, vitamin B12 and folic acid should be given together because:
Vitamin B12 acts as a cofactor for dihydrofolate reductase
Folic acid alone causes improvement of anemic symptoms but neurological dysfunction continues.
Vitamin B12 deficiency may result in methylfolate trap
Folic acid is required for conversion of methylmalonyl-CoA to succinyl CoA.
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