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Pharmacology
Methicillin resistant staphylococci do not respond to b-lactam antibiotics because:
They produce a b-lactamase which destroys methicillin and related drugs
They elaborate an amidase which destroys methicillin and related drugs
They have acquired penicillin binding protein which has low affinity for b-lactam antibiotics
They are less permeable to b-lactam antibiotics
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