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Pharmacology
A 20-year-old patient weighing 60 kg has to be prescribed an antiepileptic drug (available as 200 and 400 mg tablets) for generalized tonic-clonic seizures. The pharmacokinetic parameters and therapeutic plasma concentration of the selected drug are: Target steady-state plasma concentration (Cpss) – 6 mg/L Oral bioavailability (F) – 70% Volume of distribution (V) – 1.4 L/kg Clearance (CL) – 80 ml/hr/kg Plasma half life (t½) – 15 hours What should be the loading dose and the daily maintenance dose of the drug for this patient?
720 and 984 mg respectively
984 and 720 mg respectively
450 and 720 mg respectively
884 and 984 mg respectively
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