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Pharmacology
Loop diuretics such as furosemide act by :
Decreasing tubular reabsorption of Na+ and increase GFR
Decreasing FP secretion with resultant increase in Na+ and K+excretion
Inhibiting Na+ + K+ – 2Cl– co transporter in the medullary thick ascending limb
Inhibiting Na+ – K+exchange in the collecting duct
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