A clinical pharmacologist is gathering pharmacokinetic data during clinical trials of a new antimicrobial agent. He has already determined that the half-life of this drug is 4 hours. He began a continuous intravenous drip 24 hours ago at a rate of 10 mg/min. Blood tests after 24 hours reveal that the patient's drug plasma concentration is 20 mg/L. What is the clearance of this agent?