COX 1)o Nimesulideo Meloxicamo Nabumetone3 Selective COX-2 inhibitorso Celecoxibo Parecoxibo Rofecoxibo Etoricoxibo Lumiracoxibo Valdecoxib4 nAnalgesic-antipyretics without antiinflammatory actiono Paracetamolo Metamizolo NefopamMechanism of actiono All NSAIDs inhibit cyclooxygenase inhibit synthesis of prosaglandins.o Aspirin inhibits COX irreversibly by acetylating one of its serine residues, return of COX activity depends on synthesis of fresh enzyme.o Other NSAIDs are competitive and reversible inhibitors of COX, return of activity depends on their dissociation from the enzyme which in turn is governed by the pharmacokinetic characteristics of the compound.">