. gov/pubmed/12030843Supplemental oxygen in premature infants leads to the development of bronchopulmonary dysplasia.The Pathogenesis Involves* Vasoconstriction in the retina is an early response to oxygen that can lead to Vaso-obliteration.* Neovascularization* FibrosisOxygen causes tissue injury through the formation of reactive oxygen intermediates and peroxidation of membrane lipids.">