Explanation:Tumour Lysis Syndrome (TLS):Oncologic emergency triggered by the rapid release of intracellular material from lysing malignant cells.AKI / acute uric acid nephropathy (rapid accumulation of uric acid derived from the breakdown of nucleic acids) is central to the development of TLS.Renal failure then limits the clearance of potassium, phosphorus, and uric acid leading to hyperkalemia, hyperphosphatemia, and secondary hypocalcemia (phosphate chelation with calcium).Hypocalcemia of TLS may persist even after phosphate levels normalize, presumably because of acute deficiencies of 1,25-vitamin D.Diagnosis by Cairo-Bishop CriteriaCairo-Bishop criteriaLaboratory TLS>= 2 amongClinical TLSUric acid>= 476 umol/LLaboratory TLSPotassium>= 6 mmol/L Phosphorus>=2.1 mmol/L (children)>= 1.5 mmol/L (adults)And >=1 amongCalcium">