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Pathology
A 45-year-old man presents with weakness and wasting of the muscles of his right hand for 8 months. Physical examination shows fasciculations of the hand. The patient's speech is impaired, and 6 years later, he dies of respiratory insufficiency. Autopsy shows atrophy of ventral roots in the spinal cord. Which of the following is the most likely diagnosis?
Amyotrophic lateral sclerosis
Gerstman Straussler-Scheinker disease
Huntington disease
Multiple infarct dementia
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