Medical MCQ
MCQ Ebook
Biochemistry
Microbiology
Pathology
MCQ Subjects
Anaesthesia
Anatomy
Biochemistry
Dental
ENT
Forensic Medicine
Gynaecology & Obstetrics
Medicine
Microbiology
Ophthalmology
Orthopaedics
Pathology
Pediatrics
Pharmacology
Physiology
Psychiatry
Radiology
Skin
Social & Preventive Medicine
Surgery
Others
MCQ Exam
Anaesthesia
Anatomy
Biochemistry
Dental
ENT
Forensic Medicine
Gynaecology & Obstetrics
Medicine
Microbiology
Ophthalmology
Orthopaedics
Pathology
Pediatrics
Pharmacology
Physiology
Psychiatry
Radiology
Skin
Social & Preventive Medicine
Surgery
Others
All MCQs
Term Of Use
Privacy Policy
Contact Us
About Us
Home
Ebooks
Questions
Search
Pathology
A 4-year-old girl developed clumsiness and difficulty ambulating over 6 months. On physical examination, she showed difficulty with balance while walking, dysarthria, poor hand coordination, absent deep tendon reflexes, and a bilateral Babinski sign. Light touch and vibratory sensation were greatly diminished. There was no muscular weakness. Over the next 5 years, she developed congestive heart failure from hypertrophic cardiomyopathy. She also had hyperglycemia. At autopsy, there was increased perinuclear iron deposition within cardiac myocytes. Which of the following genetic abnormalities with trinucleotide repeat expansions was most likely present in this patient?
CAG repeats in the huntingtin gene
CGG repeats in the FMR1 gene
CTG repeats in the dystrophila myotonia-protein kinase gene
GAA repeats in the frataxin gene
Questions
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100