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Pathology
An 8-year-old boy presents with periorbital edema and throbbing headaches. His parents report that the boy had a "strep throat" 2 weeks ago. Urinalysis shows 3+ hematuria. A renal biopsy shows hypercellular glomeruli, and electron microscopic examination of glomeruli discloses subepithelial "humps." Which of the following best explains the pathogenesis of glomerulonephritis in this patient?
Antineutrophil cytoplasmic autoantibodies
Deposition of circulating immune complexes
Directly cytotoxic IgG and IgM antibodies
IgE-mediated mast cell degranulation
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