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Pathology
Cytogenetic studies in a 70-year-old woman with chronic myelogenous leukemia (CML) demonstrate a t(9;22) chromosomal translocation. Which of the following best explains the role of this translocation in the pathogenesis of leukemia in this patient?
Altered DNA methylation status
Enhanced expression of telomerase gene
Expansion of a trinucleotide repeat
Protooncogene activation
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