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Pathology
Sickle Cell anaemia all are true except
The shift from HbF to HbS occurs due to point mutation.
Microvascular occlusion is a severe complication of SCA
Deoxygenation of RBC can lead to extensive membrane damage
Adults but not children; with sickle cell disease are functionally asplenic, making them susceptible to infections caused by encapsulated bacteria, such as pneumococci.
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