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Pathology
A one year old boy presented with hepatosplenomegaly and delayed milestones. The liver biopsy and bone marrow biopsy revealed presence of histiocytes with PAS-positive Diastase-resistant material in the cytoplasm. Electron-microscopic examination of these histiocytes is most likely to reveal the presence of
Birbeck’s granules in the cytoplasm
Parallel rays of tubular structures in lysosomes
Myelin figures in the cytoplasm
Electron dense deposit in the mitochondria
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